Guilt trip

It doesn't matter if rightfully or not, the important is that the whumpee feels guilty por some reason. Might be a guilt reinforced by others, or the contrary, loved ones keeps trying to comfort them, but it's no use.

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Animes
Fullmetal Alchemist Brotherhood


 * Edward Elric has a lot of self-imposed guilt running around. For trying to get their mother back to life (and failing), for his little brother losing his body in the process, and the list keeps growing throughout the show.
 * Ep 5: Edward and Alphonse Elric both feel tremendously guilty about a little girl's fate, for not realizing sooner the father's true intentions towards her and for not being able to help afterwards.

TV Shows
Doctor Who (2005)


 * The Doctor carries a lot of guilt: for the fate of Gallifrey, for the (a lot of times) sad or tragic fate of the companions, for all the people he/she was unable to save...

Grey's Anatomy


 * 3x17: Derek Shepherd (Patrick Dempsey) tells his ex-wife that he it the one to blame for Meredith being at death's door at the moment. He thinks she drowned on purpose, as she is a good swimmer, and he should have given more attention to how she was feeling before.

Hanna


 * There's some moments throughout the series that shows Erik Heller's (Joel Kinnaman) guilt about the fate of Hanna's mother, and even about the life that Hanna has to live.

House M.D.


 * 4x16: (SPOILER) Gregory House (Hugh Laurie) is in a coma after having a seizure, and he has one last moment with Amber, who had just died. He confesses his guilt over her death, and that he doesn't want to come back because he doesn't deserve it.

Lucifer


 * 2x06: Lucifer Morningstar (Tom Ellis) killed his brother, Uriel, and now is swimming in guilt. This gets even more clear shown on his appearance and on the way he practically begs the killer of the week to shot him.
 * 2x13: Lucifer goes to Hell - by choice - to look for someone, but gets trapped into his own hell loop: killing Uriel over and over again, without control over himself.

Magnum P.I. (2018)


 * 3x09: It doesn't last longer than the episode itself, but Higgins is kidnapped and Thomas Magnum (Jay Hernandez) feels responsable for it, because he know the person who did it.

Rush


 * Ep 7: William Rush (Tom Ellis) tries a powerful drug and revisits his most traumatic day, when he almost killed a patient for going to work under chemical influence. He finally admits to himself that he was wrong.

Superman & Lois (2021)


 * 1x08: Real emotional therapy scene of Lois Lane (Elizabeth Tulloch), where she admits to herself how responsable she still feels for a miscarriage of years before, since a few circumstances at the present threw her right back into that difficult time.

S.W.A.T.


 * 1x11: David Deacon's (Jay Harrington) wife collapses unexpectedly a few weeks after a brain surgery, and now needs another delicate procedure. Deacon waits anxiously at the waiting area, and shares with the captain his guilt for "making" the wife put her dreams on hold to support his career during all these years.


 * 1x19: Jim Street's (Alex Russell) mom is about to get out of prison on parole, and he is determined to accommodate her at his house, against everyone's advice to not do it. He confesses to Chris that he considers himself responsable for her being in jail for so long, because as a kid, he didn't lie to the jury like she had told him to, about the night she killed his abusive father.

The Boys


 * Have been mentioned since the beginning that everyone blames Frenchie (Tomer Capon) for the murder of Mallorie's grandkids, but it was always angry fingers pointed and never many details. At 2x06 Frenchie finally shares what happened that night, and how he still doesn't believe that he deserves forgiveness.

The Falcon and the Winter Soldier


 * Ep 1: We see a lot of Bucky Barnes's (Sebastian Stan) guilt conscience for his days as Winter Soldier, in the form of nightmares, therapy session and specially, the interactions with the father of one of his victims.

The Night Shift


 * TC Callaham (Eoin Macken) feels responsable for his brother's death, and this guilt manifests a lot on his PTSD episodes, specially throughout Season 1.
 * 2x06: A patient suffering with dry drowning remembers Topher Zia (Ken Leung) of another person he treated during his days at the army, one that he regrets immensely of the circumstances they were in: his job was to keep the man alive, every time the waterboarding torture would go too far.

The Vampire Diaries


 * 1x20: After the detox period, Stefan Salvatore (Paul Wesley) feels all the guilt from his short time as a human feeding vampire. He chooses to stay locked up and refuses to eat.

Ti Ti Ti


 * Ep 43: Edgar Sampaio (Caio Castro) confess to Marcela the guilt he feels for having avoid his brother while growing up and many years after, for the embarrassment from Osmar's (the now dead brother) sexuality.

Transplant


 * Bashir Hamed (Hamza Haq) feels extremely guilty for his parent's death, even has moments of hallucinations about it.

Young Wallander


 * Kurt Wallander (Adam Pålsson) has enough guilt for everyone's share. He feels guilty about the boy's murder at the first episode, for not doing more, not seeing more. He feels responsable for his friend's condition at the hospital, and a lot more after that.

Movies
The Amazing Spiderman (2012)


 * As one must imagine, Peter Parker (Andrew Garfield) feels a lot of guilt for Uncle Ben's death, and kicks off his masked career searching for the killer, often returning home full of bruises.

Dramas
The Untamed


 * If there's something that Wei Wu Xian (Xiao Zhan) has more than sassiness, it's guilt. For deaths, for words, for all sort of things that happens to others, for things that he doesn't have control over. Lots and lots of angst.
 * Lan Wang Ji (Wangi Yi Bo) doesn't show it much at first, but ah, the guilt he carries. In particular about the fate of Wei Wu Xian.

Word of Honor


 * Zhou Zi Shu (Zhang Zhe Han) carries the guilt of being the last survivor of his sect, and more: for having - in some degree - some responsibility into the others deaths. Because of these feelings, he even puts himself through a long term torture method at the first episode, that lasts practically the whole show.
 * Ep 27: Wen Ke Xing's (Gong Jun) true identity being (officially) revealed to Zhou Zi Shu, he finally gives voice to the guilt he (Wen Ke Xing) feels about the death of Cheng Ling's family, and for keep lying to the young boy.